1.Bai, W., et al., Screening of MSI detection loci and their heterogeneity in East Asian colorectal cancer patients. Cancer Med, 2019. 8(5): p. 2157-2166.
2.Network, N.C.C., NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer Version 1.2021 2021.
3.Suraweera, N., et al., Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology, 2002. 123(6): p. 1804-11.
4.Umar, A., et al., Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst, 2004. 96(4): p. 261-268.
5.Marabelle, A., et al., Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study. J Clin Oncol, 2020. 38(1): p. 1-10.
6.Overman, M.J., et al., Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer. J Clin Oncol, 2018. 36(8): p. 773-779.
7.Kim, J.H., et al., A Phase II Study of Avelumab Monotherapy in Patients with Mismatch Repair-Deficient/Microsatellite Instability-High or POLE-Mutated Metastatic or Unresectable Colorectal Cancer. Cancer Res Treat, 2020. 52(4): p. 1135-1144.
8.https://clinicaltrials.gov/ct2/show/NCT03435107?term=NCT03435107&draw=2&rank=1
9.Zhang, C., et al., Incidence and detection of high microsatellite instability in colorectal cancer in a Chinese population: a meta-analysis. 2020, 2020.
10.LI X, LIU QH. Study on Microsatellite Instability in Colorectal Cancer Patients with Familial Predisposition. J China Med Univ 2006;37:410-408.
11.Jin HY, Lai RS, Ding YJ, Xie L, Yang BL, Liu F, Ding SQ, Ge YS. Detection of microsatellite instability in colorectal cancer by fluorescence multiplex polymerase chain reaction and its clinical value. Zhonghua Wei Chang Wai Ke Za Zhi. 2007 May;10(3):217-20.
12.Yang BL, Gu YF. Microsatellite instability in sporadic colorectal cancer and its relationship with clinicopathological features. World Chinese Journal of Digestology 2007;15:1160-1164.
13.Jin P, Meng XM, Sheng JQ, et al. Clinicopathological Features of Non-familial Colorectal Cancer with High-frequency Microsatellite Instability. Chin Med Sci J 2010;25:228-232.
14.Meng WJ, Wang L, Yu YY, et al. Significance of microsatellite instability in sporadic stage II and III rectal cancer. Chongqing Med J 2010;39:2420-2426.
15.Peng JL, Tang T, Ye ZL, et al. The relationship of microsatellite instability state with loss of mismatch repair proteins and clinical pathological characteristics in sporadic colorectal cancers. Chin J Cancer Biother 2015;22:479-483.
16.Zhou LY, Wan MZ, Liu YP, et al. Assessment of Microsatallite Instability in Colorectal Carcinoma: A Comparison Between Immunohistochemistry and PCR Method. Cancer Res Prev Treat 2015;42:1231-1234.
17.Yan WY, Hu J, Xie L, et al. Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population. Onco Targets Ther 2016;9:7415-7424.
18.Zheng JM, Huang BX, Nie X, et al. The clinicopathological features and prognosis of tumor MSI in East Asian colorectal cancer patients using NCI panel. Future Oncol 2018;14:1355-1364.
19.Jiang N. Relationship between microsatellite instability and clinicopathological features and prognosis in sporadic colorectal cancer. Acta Universitatis Medicinalis Anhui 2019;54:139-142.
20.Huang YQ, Yuan Y, Ge WT, et al. Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients. J Zhejiang Univ-SC B 2010;11:647-653.
21.Li WQ, Li HN, Liu RQ, et al. Comprehensive Analysis of the Relationship Between RAS and RAF Mutations and MSI Status of Colorectal Cancer in Northeastern China. Cell Physiol Biochem 2018;50:1496-1509.
22.Wang Z, Tang XL, Wu XQ, et al. Mismatch Repair status between primary colorectal tumor and metastatic tumor, a retrospective consistent study. Biosci Rep 2019;39:BSR20190730.
23.Song YL, Wang LL, Ran WW, et al. Effect of Tumor Location on Clinicopathological and Molecular Markers in Colorectal Cancer in Eastern China Patients: An Analysis of 2,356 Cases. Front Genet 2020;11:96.
24.Buhard, O., et al., Quasimonomorphic mononucleotide repeats for high-level microsatellite instability analysis. Dis Markers, 2004. 20(4-5): p. 251-7.
25.Nouri Nojadeh, J., et al., Evaluation of microsatellite instability in tumor and tumor marginal samples of sporadic colorectal cancer using mononucleotide markers. EXCLI J, 2018. 17: p. 945-951.
图 3 由于NR22位点无法兼容，NR27位点引入Pentaplex Panel
